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Article

Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets

26 May 2022

Abstract excerpt

In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR) dependence leads to clinically aggressive tumors with few therapeutic options. We used ATAC-seq (assay for transposase-accessible chromatin sequencing), RNA-seq, and DNA sequencing to investigate 22 organoids, six patient-derived xenografts, and 12 cell lines. We identified the well-characterized AR-dependent and neuroendocrine...

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PMID: 35617398
DOI: 10.1126/science.abe1505

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