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Article

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome.

Virology - 1 Nov 2015

Nieto-Torres Jose L, Verdiá-Báguena Carmina, Jimenez-Guardeño Jose M, Regla-Nava Jose A, Castaño-Rodriguez Carlos, Fernandez-Delgado Raul, Torres Jaume, Aguilella Vicente M, Enjuanes Luis

Abstract excerpt

Severe acute respiratory syndrome coronavirus (SARS-CoV) envelope (E) protein is a viroporin involved in virulence. E protein ion channel (IC) activity is specifically correlated with enhanced pulmonary damage, edema accumulation and death. IL-1β driven proinflammation is associated with those pathological signatures, however its link to IC activity remains unknown. In this report, we demonstrate that SARS-CoV E...

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Source

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Identifiers

PMID: 26331680
DOI: 10.1016/j.virol.2015.08.010
PMCID: PMC4619128

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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