Article

SARS-CoV-2 Orf6 Triggers MTCH1-Dependent Mitochondrial Dysfunction and Necroptosis in Human Neurons

2025-09-08

Abstract excerpt

<title>Abstract</title> <p>The molecular basis of neuronal damage in SARS-CoV-2 infection remains elusive. Here, we identify the viral accessory protein Orf6 as a key driver of necroptotic neuronal death. Through a systematic screen of 22 structural and non-structural SARS-CoV-2 proteins, Orf6 emerged to be the most cytotoxic to human cells. In primary human neurons, Orf6 selectively activates the necroptotic pat...

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Literature Corpus work: 40e460f4-7431-5bdc-9f12-09a53f45e844
DOI: 10.21203/rs.3.rs-7291444/v1

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