Article

Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity

2020-09-19

Abstract excerpt

Axon loss underlies symptom onset and progression in many neurodegenerative disorders. Axon degeneration in injury and disease is promoted by activation of the nicotinamide adenine dinucleotide (NAD)-consuming enzyme SARM1 (sterile alpha and TIR motif-containing protein 1). Here, we report vacor mononucleotide (VMN), a metabolite of the pesticide and neurotoxin vacor, as the most potent yet SARM1 activator. Remova...

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Literature Corpus work: 2f88aff6-34c0-579a-a8d4-8c57f78cbcea
DOI: 10.1101/2020.09.18.304261

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