Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo Efficacy

18 Mar 2025

Abstract excerpt

Sterile alpha and TIR Motif Containing 1 (SARM1) is a nicotinamide adenine dinucleotide (NAD + ) hydrolase that plays a central role in programmed axonal degeneration. Axonal degeneration has been linked to neurodegenerative and neurological disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, and peripheral neuropathies. Therefore, developing potent and selective SARM1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress and Disease
Share to Enzyme function and inhibition
Share to Peptidase Inhibition and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40100796
DOI: 10.1021/acs.jmedchem.4c03127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of a Potent SARM1 Base-Exchange Inhibitor with In Vivo EfficacyPMID 40100796Read ↗

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low dosesSemantic proximity Read ↗

Acidic pH irreversibly activates the signaling enzyme SARM1.Semantic proximity Read ↗

SARM1, the executioner of axon degeneration, is an ADP-ribosyl transferase and autoMARylation negatively regulates its activationSemantic proximity Read ↗

Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicitySemantic proximity Read ↗

Small Molecule SARM1 Inhibitors Recapitulate the SARM1-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.Semantic proximity Read ↗

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1Semantic proximity Read ↗

Adaptation of a commercial NAD quantification kit to assay the base exchange activity of SARM1Semantic proximity Read ↗

Gene therapy targeting SARM1 blocks pathological axon degeneration in miceSemantic proximity Read ↗

High-Throughput Targeted Drug Screening for NF1-associated High-Grade Gliomas with ATRX DeficiencySemantic proximity Read ↗

Constitutively active <i>SARM1</i> variants found in ALS patients induce neuropathySemantic proximity Read ↗

Structural basis for resistance to diverse classes of NAMPT inhibitors.Semantic proximity Read ↗

A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP IISemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.