Article

Efficient Targeted Delivery of Bifunctional Circular Aptamer ASO Chimera to Suppress the SARS-CoV-2 Proliferation and Inflammation

2022-10-14

Abstract excerpt

<title>Abstract</title> Inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and excessive inflammation is the current task in the prevention and treatment of COVID-19. Here, we designed a dual-function circular aptamerASO chimera (circSApt-NASO) to suppress SARS-CoV-2 replication and inflammation. The chemically unmodified circSApt-NASO exhibited high serum stability by artific...

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Literature Corpus work: 2f87af4c-efc8-5001-a4e6-e842d40af80b
DOI: 10.21203/rs.3.rs-2154742/v1

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