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Article

Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape.

Journal of the American Chemical Society - 29 Dec 2021

Sun Miao, Liu Siwen, Song Ting, Chen Fude, Zhang Jialu, Huang Jia-Ao, Wan Shuang, Lu Yao, Chen Honglin, Tan Weihong, Song Yanling, Yang Chaoyong

Abstract excerpt

New neutralizing agents against SARS-CoV-2 and associated mutant strains are urgently needed for the treatment and prophylaxis of COVID-19. Herein, we develop a spherical cocktail neutralizing aptamer-gold nanoparticle (SNAP) to block the interaction between the receptor-binding domain (RBD) of SARS-CoV-2 and host ACE2. With the multivalent aptamer assembly as well as the steric hindrance effect of the gold...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34855379
DOI: 10.1021/jacs.1c08226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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