Article

DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2

2020-07-23

Abstract excerpt

DNA aptamers are versatile molecular species obtained by the folding of short single-stranded nucleotide sequences, with highly specific recognition capabilities against proteins. Here we test the ability of selected DNA aptamers in interacting with the spike (S-)protein of the SARS-CoV-2 viral capsid. The S-protein, a trimer made up of several subdomains, develops the crucial function of recognizing the ACE2 r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be76a3f8-2ffc-5075-8cee-cfacb015c090
DOI: 10.26434/chemrxiv.12696173.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2DOI 10.26434/chemrxiv.12696173.v1Read

A SARS‐CoV‐2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD‐Independent Mechanism**Semantic proximity Read

SELEX based aptamers with diagnostic and entry inhibitor therapeutic potential for SARS-CoV-2Semantic proximity Read

SELEX based aptamers with diagnostic and entry inhibitor therapeutic potential for SARS-CoV-2Semantic proximity Read

DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic.Semantic proximity Read

Broadly neutralizing aptamers to SARS-CoV-2: A diverse panel of modified DNA antiviral agentsSemantic proximity Read

Elucidating the molecular docking and binding dynamics of aptamers with spike proteins across SARS-CoV-2 variants of concernSemantic proximity Read

Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein.Semantic proximity Read

Domains and Functions of Spike Protein in Sars-Cov-2 in the Context of Vaccine Design.Semantic proximity Read

One Solution for All: Searching for Universal Aptamers for Constantly Mutating Spike Proteins of SARS‐CoV‐2Semantic proximity Read

In-Silico Selection of Aptamer Targeting SARS-CoV-2 Spike ProteinSemantic proximity Read

Peptide Scanning of SARS-CoV and SARS-CoV-2 Spike Protein Subunit 1 Reveals Potential Additional Receptor Binding SitesSemantic proximity Read

Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape.Semantic proximity Read