Article
A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry.
Proceedings of the National Academy of Sciences of the United States of America - 14 Dec 2021
Valero Julián, Civit Laia, Dupont Daniel M, Selnihhin Denis, Reinert Line S, Idorn Manja, Israels Brett A, Bednarz Aleksandra M, Bus Claus, Asbach Benedikt, Peterhoff David, Pedersen Finn S, Birkedal Victoria, Wagner Ralf, Paludan Søren R, Kjems Jørgen
Abstract excerpt
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created an urgent need for new technologies to treat COVID-19. Here we report a 2'-fluoro protected RNA aptamer that binds with high affinity to the receptor binding domain (RBD) of SARS-CoV-2 spike protein, thereby preventing its interaction with the host receptor ACE2. A trimerized version of the RNA aptamer matching the three RBDs in...
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