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Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs

27 Oct 2021

Abstract excerpt

Circular RNAs (circRNAs) are noncoding RNAs that exist in all eukaryotes investigated and are derived from back-splicing of certain pre-mRNA exons. Here, we report the application of artificial circRNAs designed to act as antisense-RNAs. We systematically tested a series of antisense-circRNAs targeted to the SARS-CoV-2 genome RNA, in particular its structurally conserved 5'-untranslated region. Functional assays...

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PMID: 34850109
DOI: 10.1093/nar/gkab1096

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