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TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity

19 Feb 2025

Abstract excerpt

Lung macrophages play a pivotal role in pulmonary fibrosis, with monocyte-derived alveolar macrophages driving disease progression. However, the mechanisms regulating their pro-fibrotic behavior and survival remain unclear, and effective therapeutic strategies are lacking. Here we show that triggering receptors expressed on myeloid cells 2 are predominantly expressed on monocyte-derived alveolar macrophages in...

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PMID: 39971937
DOI: 10.1038/s41467-025-57024-0

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