Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma.

doi:10.1186/s13073-021-00931-w

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Article

Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma.

Genome medicine - 14 Jul 2021

Meiller Clément, Montagne François, Hirsch Theo Z, Caruso Stefano, de Wolf Julien, Bayard Quentin, Assié Jean-Baptiste, Meunier Léa, Blum Yuna, Quetel Lisa, Gibault Laure, Pintilie Ecaterina, Badoual Cécile, Humez Sarah, Galateau-Sallé Françoise, Copin Marie-Christine, Letouzé Eric, Scherpereel Arnaud, Zucman-Rossi Jessica, Le Pimpec-Barthes Françoise, Jaurand Marie-Claude, Jean Didier

Abstract excerpt

BACKGROUND: Malignant pleural mesothelioma (MPM) is a heterogeneous cancer. Better knowledge of molecular and cellular intra-tumor heterogeneity throughout the thoracic cavity is required to develop efficient therapies. This study focuses on molecular intra-tumor heterogeneity using the largest series to date in MPM and is the first to report on the multi-omics profiling of a substantial series of multi-site...

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Identifiers

PMID: 34261524
DOI: 10.1186/s13073-021-00931-w
PMCID: PMC8281651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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