Multiomic, Histologic, and scRNA-seq Profiling of Pleural Mesothelioma Reveals Negative Prognosis Associated With a Novel Uncommitted Molecular Phenotype.

doi:10.1016/j.jtho.2025.11.019

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Article

Multiomic, Histologic, and scRNA-seq Profiling of Pleural Mesothelioma Reveals Negative Prognosis Associated With a Novel Uncommitted Molecular Phenotype.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2026

Severson David T, Freyaldenhoven Samuel, Wadowski Benjamin, Hung Yin P, Hughes Travis, Yeap Beow Y, Richards William G, Laaksonen Sanna, Chirieac Lucian, Couger Matthew B, Jensen Roderick V, Sadek Ahmed A, Ilonen Ilkka, Vermilya Kimberly, Innocenti Simona, Korle Stephanie L, Barlow Julianne S, Anderson Jamie, Meyerovitz Jason, Wang Vivian, Dao Mary N, Shalek Alex K, De Rienzo Assunta, Bueno Raphael

Abstract excerpt

INTRODUCTION: Multiomics pleural mesothelioma (PM) studies have identified prognostic molecular subsets of PM histologic types, epithelioid (ePM), biphasic (bPM), and sarcomatoid (sPM), defined by relative tumor cell content. However, the underlying biology modulating survival remains unknown. METHODS: Using 93 samples from 40 patients, we performed single-cell RNA sequencing (scRNA-seq), bulk exome and RNA...

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Identifiers

PMID: 41319863
DOI: 10.1016/j.jtho.2025.11.019
PMCID: PMC12853269

Genes

AXL
GAS6
MEST
MSLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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