Article

Redefining mesothelioma types as a continuum uncovers the immune and vascular systems as key players in the diagnosis and prognosis of this disease

2018-05-30

Abstract excerpt

<h4>Summary</h4> Malignant Pleural Mesothelioma (MPM) is an aggressive disease related to asbestos exposure, which incidence is expected to increase in the future, and with no effective therapeutic options. We have performed unsupervised analyses of publicly available RNAseq data for 297 MPM. We found that the molecular profile and the prognosis of this disease is better explained by a continuous model rather tha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3b2fbd88-40e4-5ee4-9cc0-ecc076827785
DOI: 10.1101/334326

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Redefining mesothelioma types as a continuum uncovers the immune and vascular systems as key players in the diagnosis and prognosis of this diseaseDOI 10.1101/334326Read

Progress and challenges in Mesothelioma: From bench to bedside.Semantic proximity Read

Spatially resolved, high-dimensional transcriptomics sorts out the evolution of biphasic malignant pleural mesothelioma: new paradigms for immunotherapySemantic proximity Read

Genomics and Functional Genomics of Malignant Pleural MesotheliomaSemantic proximity Read

Integrative Molecular Characterization of Malignant Pleural Mesothelioma.Semantic proximity Read

A molecular phenotypic map of Malignant Pleural MesotheliomaSemantic proximity Read

Integrative transcriptome analysis of malignant pleural mesothelioma reveals a clinically relevant immune-based classificationSemantic proximity Read

Multiple institutions’ research findings using the National Mesothelioma Virtual BankSemantic proximity Read

Genomics and Epigenetics of Malignant MesotheliomaSemantic proximity Read

Single cell view of tumor microenvironment gradients in pleural mesotheliomaSemantic proximity Read

Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applicationsSemantic proximity Read

Disentangling heterogeneity of Malignant Pleural Mesothelioma through deep integrative omics analysesSemantic proximity Read

Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneitySemantic proximity Read