Article

A phenotype-based forward genetic screen identifies <i>Dnajb6</i> as a sick sinus syndrome gene

2022-01-26

Abstract excerpt

Sick sinus syndrome (SSS) is a group of heart rhythm disorders caused by malfunction of the sinus node, the heart’s primary pacemaker. Partially owing to its aging-associated phenotypic manifestation and low expressivity, molecular mechanisms of SSS remain difficult to decipher. Here, we aim to develop a phenotype-based forward genetic approach in the zebrafish ( Danio rerio ) animal model for discovering essenti...

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Literature Corpus work: 2f6d02ec-6ba0-56b9-ada7-30c2e2fd79d0
DOI: 10.1101/2022.01.25.477752

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