Article

The Brugada syndrome associated gene <i>WT1</i> impacts on <i>SCN5A</i> expression and cardiac conduction

2025-01-20

Abstract excerpt

Brugada syndrome (BrS) is an inherited cardiac arrhythmic disorder caused by conduction slowing primarily affecting the right ventricular (RV) outflow tract (RVOT). A recent genome-wide association study (GWAS) implicated a genomic region in chromosome 11, overlapping the transcription factor WT1 , in BrS susceptibility. Here, we investigated the role of WT1 on cardiac conduction using a heterozygous knockout mo...

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Literature Corpus work: 4e251947-9b0d-5753-9cbe-411159c3434f
DOI: 10.1101/2025.01.16.633330

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