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Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy

28 Apr 2022

Abstract excerpt

Modifier genes contribute significantly to our understanding of pathophysiology in human diseases; however, effective approaches to identify modifier genes are still lacking. Here, we aim to develop a rapid F0-based genetic assay in adult zebrafish using the bag3 gene knockout (bag3e2/e2) cardiomyopathy model as a paradigm. First, by utilizing a classic genetic breeding approach, we identified dnajb6b as a...

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PMID: 35481478
DOI: 10.1242/dmm.049427

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