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Article

A Functional Assay for Sick Sinus Syndrome Genetic Variants.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2017

Jou Chuanchau J, Arrington Cammon B, Barnett Spencer, Shen Jiaxiang, Cho Scott, Sheng Xiaoming, McCullagh Patrick C, Bowles Neil E, Pribble Chase M, Saarel Elizabeth V, Pilcher Thomas A, Etheridge Susan P, Tristani-Firouzi Martin

Abstract excerpt

BACKGROUND/AIMS: Congenital Sick Sinus Syndrome (SSS) is a disorder associated with sudden cardiac death due to severe bradycardia and prolonged pauses. Mutations in HCN4, the gene encoding inward Na+/K+ current (If), have been described as a cause of congenital SSS. The objective of this study is to develop an SSS model in embryonic zebrafish, and use zebrafish as a moderate-throughput assay to functionally...

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Source

Identifiers

PMID: 28803248
DOI: 10.1159/000479897

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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