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A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene

7 Sept 2016

Abstract excerpt

Mutagenesis screening is a powerful forward genetic approach that has been successfully applied in lower-model organisms to discover genetic factors for biological processes. This phenotype-based approach has yet to be established in vertebrates for probing major human diseases, largely because of the complexity of colony management. Herein, we report a rapid strategy for identifying genetic modifiers of...

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PMID: 27642634
DOI: 10.1172/jci.insight.88797

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