An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice.

doi:10.1073/pnas.2218204121

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Article

An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice.

Proceedings of the National Academy of Sciences of the United States of America - 23 Apr 2024

Okabe Yuta, Murakoshi Nobuyuki, Kurebayashi Nagomi, Inoue Hana, Ito Yoko, Murayama Takashi, Miyoshi Chika, Funato Hiromasa, Ishii Koichiro, Xu Dongzhu, Tajiri Kazuko, Qin Rujie, Aonuma Kazuhiro, Murakata Yoshiko, Song Zonghu, Wakana Shigeharu, Yokoyama Utako, Sakurai Takashi, Aonuma Kazutaka, Ieda Masaki, Yanagisawa Masashi

Abstract excerpt

Inherited arrhythmia syndromes (IASs) can cause life-threatening arrhythmias and are responsible for a significant proportion of sudden cardiac deaths (SCDs). Despite progress in the development of devices to prevent SCDs, the precise molecular mechanisms that induce detrimental arrhythmias remain to be fully investigated, and more effective therapies are desirable. In the present study, we screened a large-scale...

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PMID: 38621141
DOI: 10.1073/pnas.2218204121
PMCID: PMC11047072

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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