Article
A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene.
eLife - 18 Oct 2022
Ding Yonghe, Lang Di, Yan Jianhua, Bu Haisong, Li Hongsong, Jiao Kunli, Yang Jingchun, Ni Haibo, Morotti Stefano, Le Tai, Clark Karl J, Port Jenna, Ekker Stephen C, Cao Hung, Zhang Yuji, Wang Jun, Grandi Eleonora, Li Zhiqiang, Shi Yongyong, Li Yigang, Glukhov Alexey V, Xu Xiaolei
Abstract excerpt
Previously we showed the generation of a protein trap library made with the gene-break transposon (GBT) in zebrafish (Danio rerio) that could be used to facilitate novel functional genome annotation towards understanding molecular underpinnings of human diseases (Ichino et al, 2020). Here, we report a significant application of this library for discovering essential genes for heart rhythm disorders such as sick...
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