Article
Genetic and physiologic dissection of the vertebrate cardiac conduction system.
PLoS biology - 13 May 2008
Chi Neil C, Shaw Robin M, Jungblut Benno, Huisken Jan, Ferrer Tania, Arnaout Rima, Scott Ian, Beis Dimitris, Xiao Tong, Baier Herwig, Jan Lily Y, Tristani-Firouzi Martin, Stainier Didier Y R
Abstract excerpt
Vertebrate hearts depend on highly specialized cardiomyocytes that form the cardiac conduction system (CCS) to coordinate chamber contraction and drive blood efficiently and unidirectionally throughout the organism. Defects in this specialized wiring system can lead to syncope and sudden cardiac death. Thus, a greater understanding of cardiac conduction development may help to prevent these devastating clinical...
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