Article

Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying Drug

2025-05-27

Abstract excerpt

Calcium dysregulation, caused by pathological activation of ryanodine receptors, contributes to motor neuron degeneration, motor dysfunction, and muscle weakness in SOD1-G93A transgenic amyotrophic lateral sclerosis (ALS) mice. This study investigates the therapeutic efficacy of intranasally administered dantrolene nanoparticles, a ryanodine receptor antagonist, on motor neuron function, muscle strength, spinal co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f50f8b8-0e23-5a5a-8f2e-c4a48c93a4ef
DOI: 10.1101/2025.05.21.655232

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intranasal Dantrolene Nanoparticles for Treatment of Amyotrophic Lateral Sclerosis as a Disease-Modifying DrugDOI 10.1101/2025.05.21.655232Read

AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model miceSemantic proximity Read

P2X7 Receptor Antagonism as a Potential Therapy in Amyotrophic Lateral SclerosisSemantic proximity Read

Chronic Administration of Pimozide Fails to Attenuate Motor and Pathological Deficits in Two Mouse Models of Amyotrophic Lateral Sclerosis.Semantic proximity Read

A Phase 1b/2a Clinical Trial of Dantrolene Sodium in Patients with Wolfram SyndromeSemantic proximity Read

Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosisSemantic proximity Read

Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibitionSemantic proximity Read

Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis.Semantic proximity Read

Improving Motor Function in Amyotrophic Lateral Sclerosis: The impact of Triumeq on a TDP-43 mouse modelSemantic proximity Read

Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1G93A Mice.Semantic proximity Read

Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosisSemantic proximity Read

[Amyotrophic lateral sclerosis--diagnosis and treatment].Semantic proximity Read

Neuromuscular effects of G93A-SOD1 expression in zebrafish.Semantic proximity Read