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Article

P2X7 Receptor Antagonism as a Potential Therapy in Amyotrophic Lateral Sclerosis

12 Jun 2020

Abstract excerpt

This review focuses on the purinergic ionotropic receptor P2X7 (P2X7R) as a potential target for developing drugs that delay the onset and/or disease progression in patients with amyotrophic lateral sclerosis (ALS). Description of clinical and genetic ALS features is followed by an analysis of advantages and drawbacks of transgenic mouse models of disease based on mutations in a bunch of proteins, particularly...

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Share to Adenosine and Purinergic Signaling
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PMID: 32595451
DOI: 10.3389/fnmol.2020.00093

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