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Article

AAV-NRIP gene therapy ameliorates motor neuron degeneration and muscle atrophy in ALS model mice

24 Jul 2024

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron (MN) degeneration, leading to neuromuscular junction (NMJ) dismantling and severe muscle atrophy. The nuclear receptor interaction protein (NRIP) functions as a multifunctional protein. It directly interacts with calmodulin or α-actinin 2, serving as a calcium sensor for muscle contraction and maintaining sarcomere...

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PMID: 39044305
DOI: 10.1186/s13395-024-00349-z

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