Article

Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosis

2019-08-29

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease commonly treated with riluzole, a small molecule that may act via modulation of glutamatergic neurotransmission. However, riluzole only modestly extends lifespan for people living with ALS and its precise mechanisms of action remain unclear. Most ALS cases are characterised by accumulation of cytoplasmic TAR DNA binding protein of 43 kDa (TDP-43),...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78484411-0405-5297-b29b-6a70a074526d
DOI: 10.1101/749846

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Riluzole does not ameliorate disease caused by cytoplasmic TDP-43 in a mouse model of amyotrophic lateral sclerosisDOI 10.1101/749846Read

Synaptic changes contribute to persistent extra-motor behaviour deficits in the rNLS8 TDP-43 mouse model of amyotrophic lateral sclerosisSemantic proximity Read

Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis.Semantic proximity Read

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanismSemantic proximity Read

Amyotrophic lateral sclerosis associated mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortexSemantic proximity Read

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism.Semantic proximity Read

Riluzole prolongs survival time and alters nuclear inclusion formation in a transgenic mouse model of Huntington's diseaseSemantic proximity Read

Chronic Administration of Pimozide Fails to Attenuate Motor and Pathological Deficits in Two Mouse Models of Amyotrophic Lateral Sclerosis.Semantic proximity Read

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in miceSemantic proximity Read

Improving Motor Function in Amyotrophic Lateral Sclerosis: The impact of Triumeq on a TDP-43 mouse modelSemantic proximity Read

Stimulation of mTOR-independent autophagy and mitophagy by rilmenidine exacerbates the phenotype of transgenic TDP-43 mice.Semantic proximity Read

Current developments in gene therapy for amyotrophic lateral sclerosisSemantic proximity Read

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in miceSemantic proximity Read