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Article

Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis.

Annals of clinical and translational neurology - 1 Oct 2020

Goldshtein Hagit, Muhire Alexandre, Petel Légaré Virginie, Pushett Avital, Rotkopf Ron, Shefner Jeremy M, Peterson Randall T, Armstrong Gary A B, Russek-Blum Niva

Abstract excerpt

OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS). METHODS: Toxicity and efficacy of Ciprofloxacin and Celecoxib were tested, each alone and in distinct ratio combinations in SOD1 G93R transgenic zebrafish model for ALS. Quantification of swimming measures following...

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Identifiers

PMID: 32915525
DOI: 10.1002/acn3.51174
PMCID: PMC7545590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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