Article
Neuromuscular effects of G93A-SOD1 expression in zebrafish.
Molecular neurodegeneration - 31 Aug 2012
Sakowski Stacey A, Lunn J Simon, Busta Angela S, Oh Sang Su, Zamora-Berridi Grettel, Palmer Madeline, Rosenberg Andrew A, Philip Stephen G, Dowling James J, Feldman Eva L
Abstract excerpt
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal disorder involving the degeneration and loss of motor neurons. The mechanisms of motor neuron loss in ALS are unknown and there are no effective treatments. Defects in the distal axon and at the neuromuscular junction are early events in the disease course, and zebrafish provide a promising in vivo system to examine cellular mechanisms and treatments for...
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