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Article

Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling

18 Aug 2022

Abstract excerpt

Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage plasticity in prostate cancer and its relationship to antiandrogen resistance. We found that plasticity initiates in an epithelial population defined by mixed...

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PMID: 35981096
DOI: 10.1126/science.abn0478

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