Article
Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance.
Science (New York, N.Y.) - 6 Jan 2017
Ku Sheng Yu, Rosario Spencer, Wang Yanqing, Mu Ping, Seshadri Mukund, Goodrich Zachary W, Goodrich Maxwell M, Labbé David P, Gomez Eduardo Cortes, Wang Jianmin, Long Henry W, Xu Bo, Brown Myles, Loda Massimo, Sawyers Charles L, Ellis Leigh, Goodrich David W
Abstract excerpt
Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse models, we demonstrate that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma...
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