Article

CRISPR-Mediated Targeting of BRAF Oncogenes in Pediatric Low-Grade Glioma

2026-08-13

Abstract excerpt

Pediatric low-grade glioma (pLGG) is the most common brain tumor of childhood, accounting for 30-50% of all pediatric central nervous system malignancies. The disease is almost universally driven by activating mutations in the BRAF serine/threonine kinase: a chromosomal tandem duplication generating the KIAA1549-BRAF oncofusion in approximately 70% of cases, or the BRAF V600E gain-of-function point mutation in app...

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Literature Corpus work: 2f083fcc-c866-53ee-a230-85ca212babfe
DOI: 10.64898/2026.08.12.744431

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