Article
Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2017
Lassaletta Alvaro, Zapotocky Michal, Mistry Matthew, Ramaswamy Vijay, Honnorat Marion, Krishnatry Rahul, Guerreiro Stucklin Ana, Zhukova Nataliya, Arnoldo Anthony, Ryall Scott, Ling Catriona, McKeown Tara, Loukides Jim, Cruz Ofelia, de Torres Carmen, Ho Cheng-Ying, Packer Roger J, Tatevossian Ruth, Qaddoumi Ibrahim, Harreld Julie H, Dalton James D, Mulcahy-Levy Jean, Foreman Nicholas, Karajannis Matthias A, Wang Shiyang, Snuderl Matija, Nageswara Rao Amulya, Giannini Caterina, Kieran Mark, Ligon Keith L, Garre Maria Luisa, Nozza Paolo, Mascelli Samantha, Raso Alessandro, Mueller Sabine, Nicolaides Theodore, Silva Karen, Perbet Romain, Vasiljevic Alexandre, Faure Conter Cécile, Frappaz Didier, Leary Sarah, Crane Courtney, Chan Aden, Ng Ho-Keung, Shi Zhi-Feng, Mao Ying, Finch Elizabeth, Eisenstat David, Wilson Bev, Carret Anne Sophie, Hauser Peter, Sumerauer David, Krskova Lenka, Larouche Valerie, Fleming Adam, Zelcer Shayna, Jabado Nada, Rutka James T, Dirks Peter, Taylor Michael D, Chen Shiyi, Bartels Ute, Huang Annie, Ellison David W, Bouffet Eric, Hawkins Cynthia, Tabori Uri
Abstract excerpt
Purpose BRAF V600E is a potentially highly targetable mutation detected in a subset of pediatric low-grade gliomas (PLGGs). Its biologic and clinical effect within this diverse group of tumors remains unknown. Patients and Methods A combined clinical and genetic institutional study of patients with PLGGs with long-term follow-up was performed (N = 510). Clinical and treatment data of patients with BRAF V600E...
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