Article

Somatic genome editing with the RCAS/TVA-CRISPR/Cas9 system for precision tumor modeling

2017-08-14

Abstract excerpt

It has been gradually established that the vast majority of human tumors are extraordinarily heterogeneous at a genetic level. To accurately recapitulate this complexity, it is now evident that in vivo animal models of cancers will require to recreate not just a handful of simple genetic alterations, but possibly dozens and increasingly intricate. Here, we have combined the RCAS/TVA system with the CRISPR/Cas9 ge...

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Identifiers and source

Literature Corpus work: 627d9c5c-191e-5251-988c-48c47a8f8ffb
DOI: 10.1101/162669

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