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Article

A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.

Molecular cell - 5 Mar 2015

McMillan Brian J, Schnute Björn, Ohlenhard Nadja, Zimmerman Brandon, Miles Laura, Beglova Natalia, Klein Thomas, Blacklow Stephen C

Abstract excerpt

Mind bomb (Mib) proteins are large, multi-domain E3 ligases that promote ubiquitination of the cytoplasmic tails of Notch ligands. This ubiquitination step marks the ligand proteins for epsin-dependent endocytosis, which is critical for in vivo Notch receptor activation. We present here crystal structures of the substrate recognition domains of Mib1, both in isolation and in complex with peptides derived from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25747658
DOI: 10.1016/j.molcel.2015.01.019
PMCID: PMC4355479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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