Article

The Role of UBE2-Conjugating Enzymes in the Mechanism of MuRF1 Ubiquitylation

2022-06-13

Abstract excerpt

<h4>ABSTRACT</h4> MuRF1 (Muscle-specific RING finger protein 1; gene name TRIM63) is a ubiquitin E3 ligase, associated with the progression of muscle atrophy. As a RING (Really Interesting New Gene)-type E3 ligase, its unique activity of ubiquitylation is driven by a specific interaction with UBE2 (ubiquitin conjugating enzyme) to ubiquitylate its substrate protein. The understanding of MuRF1 function remains unc...

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Literature Corpus work: 5fe3a0b0-bc36-5e6d-ad24-4699c4b6dc96
DOI: 10.1101/2022.06.13.495268

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