Article
The role of neoantigens in response to immune checkpoint blockade.
International immunology - 1 Aug 2016
Riaz Nadeem, Morris Luc, Havel Jonathan J, Makarov Vladimir, Desrichard Alexis, Chan Timothy A
Abstract excerpt
Immune checkpoint blockade has demonstrated substantial promise for the treatment of several advanced malignancies. These agents activate the immune system to attack tumor cells. For example, agents targeting CTLA4 and programmed cell death 1 (PD-1) have resulted in impressive response rates and, in some cases, durable remissions. Neoantigens are mutations that encode immunologically active proteins that can...
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