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Article

DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.

The Journal of biological chemistry - 12 Apr 2013

Dehennaut Vanessa, Loison Ingrid, Dubuissez Marion, Nassour Joe, Abbadie Corinne, Leprince Dominique

Abstract excerpt

HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene frequently epigenetically silenced in human cancers. HIC1 encodes a transcriptional repressor involved in the regulation of growth control and DNA damage response. We previously demonstrated that HIC1 can be either acetylated or SUMOylated on lysine 314. This deacetylation/SUMOylation switch is governed by an unusual complex made up of SIRT1 and HDAC4...

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Topics

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Etoposide

Share to Histone Deacetylases

Share to Kruppel-Like Transcription Factors

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Source

Open in PubMed Open full text

Identifiers

PMID: 23417673
DOI: 10.1074/jbc.M112.421610
PMCID: PMC3624409

Genes

HIC1
HDAC4
SIRT1
MTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.PMID 23417673Read ↗

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