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Article

Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical significance

8 Sept 2009

Abstract excerpt

This study focused on a cell cycle regulatory gene, FBXW7, which ubiquitinates c-Myc and cyclin E and promotes exit from the cell cycle. We determined the expression level of FBXW7 in colorectal cancer (CRC) cases, correlated those values with clinicopathologic features, and characterized the molecular mechanism of reduced expression of FBXW7 in CRC cells in vitro. FBXW7 mRNA and protein expression were evaluated...

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PMID: 19739118
DOI: 10.1002/ijc.24879

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