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Article

Hypermethylated in Cancer 1 (<i>HIC1</i>), a Tumor Suppressor Gene Epigenetically Deregulated in Hyperparathyroid Tumors by Histone H3 Lysine Modification

28 Apr 2012

Abstract excerpt

CONTEXT: Primary hyperparathyroidism (pHPT) resulting from parathyroid tumors is a common endocrine disorder with incompletely understood etiology. In renal failure, secondary hyperparathyroidism (sHPT) occurs with multiple tumor development as a result of calcium and vitamin D regulatory disturbance. OBJECTIVE: The aim of the study was to investigate whether HIC1 may act as a tumor suppressor in the parathyroid...

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PMID: 22544915
DOI: 10.1210/jc.2011-3136

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