Article

Excessive E2F transcription in single cancer cells precludes transient cell cycle exit after DNA damage

2020-03-20

Abstract excerpt

E2F transcription factors control the expression of cell cycle genes. Cancers often demonstrate enhanced E2F target gene expression, which can be explained by increased percentages of replicating cells. However, we now demonstrate in human cancer biopsies that individual neoplastic cells display abnormally high levels of E2F-dependent transcription. To mimic this situation, we deleted the atypical E2F repressors (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b834e3d1-c611-55a3-b292-a301343b5126
DOI: 10.1101/2020.03.19.998674

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Excessive E2F transcription in single cancer cells precludes transient cell cycle exit after DNA damageDOI 10.1101/2020.03.19.998674Read

Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA DamageSemantic proximity Read

S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues.Semantic proximity Read

E2F-7 couples DNA damage-dependent transcription with the DNA repair process.Semantic proximity Read

High-Risk But Not Low-Risk HPV E2 Proteins Bind to the APC Activators Cdh1 and Cdc20 and Cause Genomic InstabilitySemantic proximity Read

Tumor suppressor Hypermethylated in Cancer 1 represses expression of cell cycle regulator E2F7 in human primary cellsSemantic proximity Read

FOXM1 is critical for the fitness recovery of chromosomally unstable cellsSemantic proximity Read

ZNF768 regulates expression of E2F1 protein to drive G0/G1 transition and cell cycle progressionSemantic proximity Read

Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancerSemantic proximity Read

E2F and the molecular mechanisms of early cell-cycle control.Semantic proximity Read

dDP is needed for normal cell proliferation.Semantic proximity Read

The transcription factor FLI1 promotes cancer progression by affecting cell cycle regulation.Semantic proximity Read

APC/C<sup>Cdh1</sup>controls the proteasome-mediated degradation of E2F3 during cell cycle exitSemantic proximity Read