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Orphan GPCRs as Targets for Human Brain Modulation: A Multi-omic Atlas of Cell-Type Specific Expression

2026-03-24

Abstract excerpt

G Protein coupled receptors (GPCRs) are the largest class of clinically validated drug targets with nearly 35% of all approved therapeutic agents acting on these receptors. To further explore the potential of this class of receptors for the development of circuit-specific and mechanism-based therapeutic strategies for neurological disorders, we focused on GPCRs with no known endogenous ligand, orphan GPCRs (oGPCRs...

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Literature Corpus work
e3c4ab31-795a-5a80-80da-899a3961e7b9
DOI
10.64898/2026.03.23.713764
Open publication

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Orphan GPCRs as Targets for Human Brain Modulation: A Multi-omic Atlas of Cell-Type Specific ExpressionDOI 10.64898/2026.03.23.713764
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