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Article

Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities.

Nature communications - 3 Mar 2025

Loesch Douglas P, Garg Manik, Matelska Dorota, Vitsios Dimitrios, Jiang Xiao, Ritchie Scott C, Sun Benjamin B, Runz Heiko, Whelan Christopher D, Holman Rury R, Mentz Robert J, Moura Filipe A, Wiviott Stephen D, Sabatine Marc S, Udler Miriam S, Gause-Nilsson Ingrid A, Petrovski Slavé, Oscarsson Jan, Nag Abhishek, Paul Dirk S, Inouye Michael

Abstract excerpt

Genomics can provide insight into the etiology of type 2 diabetes and its comorbidities, but assigning functionality to non-coding variants remains challenging. Polygenic scores, which aggregate variant effects, can uncover mechanisms when paired with molecular data. Here, we test polygenic scores for type 2 diabetes and cardiometabolic comorbidities for associations with 2,922 circulating proteins in the UK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40032831
DOI: 10.1038/s41467-025-56695-z
PMCID: PMC11876343

Genes

EFEMP1
FAM3D
IGFBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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