Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes.

Diabetes, obesity & metabolism - 1 Dec 2025

Wei Jiahe, Wu Hanzhang, Wang Ningjian, Zhu Jiahao, Anjana Ranjit Mohan, Sokolov Aleksandr V, Schiöth Helgi B, Mohan Viswanathan, Tan Xiao

Abstract excerpt

AIMS: Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored. This study aims to investigate potential drug targets by integrating proteomics. MATERIALS AND METHODS: Summary-level data of circulating proteins were extracted from the UK...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Proteomics
Male
Female
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Sweden

Mendelian Randomization Analysis

Protein Interaction Maps

Aged

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 40888248
DOI: 10.1111/dom.70088
PMCID: PMC12587232

Genes

DAPK2
GRN
TNFSF12
CR1
LILRB5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes.PMID 40888248Read ↗

Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbiditiesSemantic proximity Read ↗

Multi-tissue multi-omics integration reveals tissue-specific pathways, gene networks and drug candidates for type 1 diabetes.Semantic proximity Read ↗

Precision medicine in type 2 diabetesSemantic proximity Read ↗

Genetic variants entail type 2 diabetes as an innate immune disorder.Semantic proximity Read ↗

Aetiological differences between novel subtypes of diabetes derived from genetic associationsSemantic proximity Read ↗

Differences in Biomarkers of Inflammation Between Novel Subgroups of Recent-Onset DiabetesSemantic proximity Read ↗

Integrative proteogenomic and observational analysis identifies potential biomarkers for latent autoimmune diabetes in adults.Semantic proximity Read ↗

Precision Medicine in Patients with Differential Diabetic Phenotypes: Novel Opportunities from Network Medicine.Semantic proximity Read ↗

Multi-omics Integration with GWAS Unveils Molecular Mechanistic Insights for Type 2 DiabetesSemantic proximity Read ↗

Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes.Semantic proximity Read ↗

Refining the Genetic Contribution to Type 2 Diabetes Subtypes.Semantic proximity Read ↗

Integrating Genetics and the Plasma Proteome to Predict the Risk of Type 2 DiabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.