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Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells

22 Jun 2015

Abstract excerpt

Unveiling the regulatory pathways maintaining hepatic stellate cells (HSC) in a quiescent (q) phenotype is essential to develop new therapeutic strategies to treat fibrogenic diseases. To uncover the miRNA-mRNA regulatory interactions in qHSCs, HSCs were FACS-sorted from healthy livers and activated HSCs (aHSCs) were generated in vitro. MiRNA Taqman array analysis showed HSCs expressed a low number of miRNAs (n =...

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PMID: 26096707
DOI: 10.1038/srep11549

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