Article
KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis.
Cell death and differentiation - 1 Jun 2007
Sirach E, Bureau C, Péron J M, Pradayrol L, Vinel J P, Buscail L, Cordelier P
Abstract excerpt
Hepatocellular carcinoma (HCC) is a major public health concern because of the absence of early diagnosis and effective treatments. Efficient diagnosis modalities and therapies to treat HCC are needed. Kruppel-like factor (KLF) family members, such as KLF6, are involved in cell proliferation and differentiation. KLF6 is inactivated in solid tumors, which may contribute to pathogenesis. However, KLF6 status in HCC...
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