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Article

Hepatocyte nuclear factor 4α induces a tendency of differentiation and activation of rat hepatic stellate cells.

World journal of gastroenterology - 21 May 2015

Liu Kai, Guo Ming-Gao, Lou Xiao-Li, Li Xiao-Ya, Xu Yang, Ji Wei-Dan, Huang Xuan-Dong, Yang Jia-He, Duan Ji-Cheng

Abstract excerpt

AIM: To investigate the effect of hepatocyte nuclear factor 4α (HNF4α) on the differentiation and transformation of hepatic stellate cells (HSCs). METHODS: By constructing the recombinant adenovirus vector expressing HNF4α and HNF4α shRNA vector, and manipulating HNF4α expression in HSC-T6 cells, we explored the influence of HNF4α and its induction capacity in the differentiation of rat HSCs into hepatocytes....

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Identifiers

PMID: 26019449
DOI: 10.3748/wjg.v21.i19.5856
PMCID: PMC4438019

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AFP
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