Article
Induction of premature senescence and a less-fibrogenic phenotype by programmed cell death 4 knockdown in the human hepatic stellate cell line Lieming Xu-2.
Human cell - 1 Mar 2023
Perveen Rasheda, Ozaki Iwata, Manirujjaman M, Mine Keiichiro, Murata Yuzo, Tanaka Kenichi, Xia Jinghe, Takahashi Hirokazu, Anzai Keizo, Matsuhashi Sachiko
Abstract excerpt
Although programmed cell death 4 (PDCD4) was initially reported as a tumor suppressor and has been shown to inhibit cancer cell growth and metastasis, recent studies have demonstrated that loss of PDCD4 expression also induces growth inhibition by inducing apoptosis and/or cellular senescence. At present, the roles of PDCD4 in the activation and profibrogenic properties of myofibroblasts, which are critically...
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