Article

Pre-existing chromatin accessibility primes δ-cells for injury-induced endocrine plasticity

2026-05-27

Abstract excerpt

Adult zebrafish rapidly recover glucose homeostasis after β-cell loss, but the cellular basis and regulatory mechanisms that enable this response remain unclear. Here we combine single-cell transcriptomics, single-cell chromatin accessibility profiling, paired multiome analysis and functional perturbation to define early pancreatic recovery after β-cell ablation. We show that, during the first month after injury,...

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Literature Corpus work: 4d38e29d-9f05-5066-837c-263541f4fa7c
DOI: 10.64898/2026.05.24.727280

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