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Article

RNA splicing and splicing regulator changes in prostate cancer pathology

5 Apr 2017

Abstract excerpt

Changes in mRNA splice patterns have been associated with key pathological mechanisms in prostate cancer progression. The androgen receptor (abbreviated AR) transcription factor is a major driver of prostate cancer pathology and activated by androgen steroid hormones. Selection of alternative promoters by the activated AR can critically alter gene function by switching mRNA isoform production, including creating...

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PMID: 28382513
DOI: 10.1007/s00439-017-1792-9

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