Article

Dysregulation of splicing-related proteins in prostate cancer is controlled by FOXA1

2018-12-31

Abstract excerpt

Prostate cancer (PCa) is genomically driven by dysregulation of transcriptional networks involving the transcriptional factors (TFs) FOXA1, ERG, AR, and HOXB13. However, the role of these specific TFs in the regulation of alternative pre-mRNA splicing (AS), which is a proven therapeutic vulnerability for cancers driven by the TF MYC, is not described. Using transcriptomic datasets from PCa patients, we tested for...

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Literature Corpus work: 561ac7b3-7d6b-5a6c-9fd8-72ea60de759c
DOI: 10.1101/509034

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